Collisions between cars and commercial vehicles (trucks) are common. When such collisions occur at relatively medium to high speeds, they have a significant effect on potential occupant injuries. Given the differences in mass (and most often and speed) between vehicles involved in such collisions the magnitude of injuries is significantly higher in the occupants of the car. Significant differences in the extent of injuries also occur due to completely different stiffnesses of the affected areas in the event of collisions between cars and trucks. This paper aims to assess the severity of potential injuries to car occupants by experimentally determining specific collision parameters, taking into account three different impact scenarios between a car and a truck.