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This paper presents an integrated numerical and experimental approach for investigating engine lubrication performance and associated wear phenomena in heavy-duty internal combustion engines. A mesh-free CFD approach based on Smoothed Particle Hydrodynamics (SPH) implemented in AVL PreonLab software was used to enable the accurate, enabling the accurate simulation of transient multiphase oil flow, including free-surface behavior, splashing, and interaction with moving engine components. Special attention is given to numerical stability and solution accuracy, including time-step control based on Courant–Friedrichs–Lewy (CFL) criteria and appropriate boundary condition definition. The simulations provide detailed insight into lubricant distribution, aeration effects, and potential lubrication deficiencies in critical regions. To support and validate the numerical model, parameters determined in the laboratory by analyzing samples of used oil are implemented. The samples were collected from heavy-duty trucks at predefined operational intervals and analyzed to determine wear-related indicators. The proposed approach contributes to a comprehensive description and understanding of wear mechanisms, lubrication effectiveness, lubricant degradation, which leads to improved prediction of maintenance strategies.